Saturday, January 07, 2012

Elect D P Maur for a corruption free government

We welcome his candidature-Dr. Arun Mitra

We welcome the candidature of
D P Maur
to the assembly elections by the Sanjha Morcha of Pubjab People’s Party,
Communist Party of India
(CPI), CPI(M),  and
Akalidal Longowal
from Ludhiana West constituency. We appeal to the voter of the constituency to elect him for a corruption free government, economic growth and jobs for all.

Ludhiana West constituency has a distinct place throughout Punjab as it has large number of highly educated, entrepreneur and conscious voters. Therefore we appeal to the voters to send D P Maur to the assembly who is time tested for his dedication towards inclusive economic growth, communal harmony and a corruption free society.

The continuous rule by the Akali BJP and Congress in the Punjab has pushed the state into a debt of Rs.138000 crores. One third of the states income is paid back in the form of interest. This has led to the deterioration in the development of Punjab. As a result there is rampant corruption, unemployment, poverty, drug addiction and lawlessness. Education and health care have become out of reach of vast majority of the population. People demanding their rights have to face lathies by the state machinery.

Due to apathetical attitude towards needs of people of Punjab of the alternative ruling parties, the feeling has evolved among the voters that they have to choose between the two evils. But now the people have a choice in the form of SANJHA MORCHA.
D P Maur has a glorious record of serving the people of the area. He remained President of the PAU Employees Union continuously for 12 years by winning 6 bi-annual elections in a row from 1995 to 2007. He is presently General Secretary of the Joint Council of Trade Unions which comprises of 17 unions/associations of Ludhiana including bank employees, hospitals, construction workers, government employees, PAU, school teachers, Class IV employees, roadways and railways employees. Besides he is also involved in various social activities like promotion of healthy environment, traffic management, uplift of the lower economic strata through basic education.
We all  Miter Sen Meet – Navel writer, Dr Arun Mitra – Former President IMA, Naval Chibber Former President Bar Association Ludhiana, Ramesh Rattan, City Secretary CPI Ludhiana, Dr D.S.Sidhu – President, Sukhminder Lotey – City Secretary CPI Ludhiana, Amarjit Singh Matoo CPI, Dev Raj of CPI, Rajesh Gandhi – PPP State General Council, Anand Sharma PPP General Council Member, Jagjeet Singh Ghugrana -  General Secretary PPP, Bharat Bhushan Thapar – General Secretary PPP, Jaskirat Singh Sargoda – Youth Leader PPP, Arun Rattan, Secretary CA Association Ludhiana, Gurcharan Kaur Kochhar – President Punjab Istri Sabha, Jit Kumar – General Secretary – Punjab Istri Sabha, Maj. (Retd.) Sher Singh Aulukh – General Secretary Ex-Serviceman Welfare Association, O P Mehta Advocate appeal to vote, support and elect D P Maur from Ludhiana West.

Military's Groundbreaking Vaccine

Targets Breast Cancer

By Elaine Sanchez
American Forces Press Service

SAN ANTONIOJan. 6, 2012 - Military researchers here have developed a cutting-edge cancer vaccine that's slashing breast cancer recurrence rates and giving some survivors a better shot at a cancer-free future.
Click photo for screen-resolution image
Army Col. (Dr.) George E. Peoples explains how cancer vaccines help to combat breast cancer during an interview at San Antonio Military Medical Center. Peoples, director and principal investigator for the Cancer Vaccine Development Program, has helped to develop a vaccine that's offering breast cancer survivors hope for a cancer-free future. DOD photo by Linda Hosek 
After more than a decade of research and testing, the cancer vaccine, dubbed E-75, soon will move on to its final phase of testing to earn Food and Drug Administration approval, said Army Col. (Dr.) George E. Peoples, director and principal investigator for the Cancer Vaccine Development Program at San Antonio Military Medical Center here.The team has high hopes for this vaccine and its lifesaving potential for breast cancer survivors, particularly since breast cancer is the most prevalent type of cancer seen among military beneficiaries in the hospital here, said Peoples, who also serves here as the deputy director of the U.S. Military Cancer Institute and the medical center's chief of surgical oncology.
"We've made a commitment to take care of active-duty personnel, spouses and retirees," the colonel said. "And cancer is a notable problem among beneficiaries."
The vaccine, Peoples explained, targets a protein commonly over-expressed in breast cancer cells called human epidermal growth factor receptor 2, or HER2/neu.
Cancer vaccines typically target some protein or antigen expressed on cancer cells, he noted. "The idea is to train the immune system to recognize that protein or piece of protein that's highly expressed on cancer cells, but not on normal cells," he said. "That way the immune system can differentiate what's abnormal and normal. If the immune system can recognize it, it marks it for death, basically."
The cancer vaccine concept has been around for a long time, Peoples noted, but the team here has adopted a different approach to test their effectiveness. The vast majority of vaccines in the past were tested on end-stage cancer patients, he explained. However, a vaccine is meant to stimulate the immune system, and a healthy immune system isn't typically seen in someone in the last stages of cancer.
As a result, "a lot of early cancer vaccines tested ... in end-stage patients were found not to be helpful," Peoples said. "No real surprise there."
To more appropriately gauge the vaccine's effectiveness, Peoples' team decided to test it among patients who have a healthy immune system -- cancer survivors who are disease-free but at risk for recurrence. Experts can predict recurrence based on several factors including family history, age, size of tumor and the presence of involved lymph nodes, among other indicators.
The researchers targeted the HER2/neu protein, which is expressed at varying levels in women with breast cancer, then honed in on the 60 percent of women who express the protein at low to intermediate levels. The vaccine is a mix of the E-75 peptide of the HER2 protein and an immune system stimulant.
They started with a 200-patient trial in 2001 and followed each woman for five years. Half of the women received the vaccine -- one injection a month for six months -- and the other half was the control group.
The outcome was very promising, Peoples noted. The recurrence rate among the women in the control group was 20 percent, and 10 percent among the women who received the vaccine. "We cut recurrence in half," he said.
This success led to the next phase of testing, the colonel said, which will begin early this year and involve 700 to 1,000 patients.
Unlike the earlier phases, however, this step will be undertaken by a commercial company, Galena Biopharma, which has the resources and manpower to undertake such a large-scale test. The company will seek FDA approval and, if received, release the vaccine for public use.
This phase will take about five years to complete -- two years to enroll, then a three-year observation period, Peoples said.
"The end point is the recurrence rate after three years," he explained.

Meanwhile, Peoples and his team will turn their attention to a multitude of other projects, many based on the same concept that made the E-75 vaccine so successful -- using the body's own immune system to destroy cancer cells.
They've already taken the same vaccine and completed a trial with prostate cancer survivors. As with ovarian and lung cancer, prostate cancer also expresses the HER2 protein.
Peoples said he's also intrigued by a successful trial they conducted on breast cancer survivors who express the HER2 protein at the highest levels, rather than the low to intermediate levels they focused on before. In this study, they combined their vaccine with the drug Herceptin.
They conducted a small trial with 60 women, Peoples said, and when they administered the vaccine and Herceptin together, the recurrence rate dropped to zero. "The preliminary data is very exciting," he said. "But we need to wait and do larger trials."
Word has spread of the cancer vaccine program's successes and intriguing results. Military and civilian experts have approached Peoples wanting to take part in research that has such a potentially widespread impact. The idea of active, specific immunotherapy -- engaging the body's immune system to do the work of fighting the cancer -- is an exciting and rapidly evolving area, Peoples explained.
Garnering this interest, Peoples has steadily built a worldwide network of military and civilian hospitals that can assist with clinical trials and research. The network includes just about every major military hospital alongside a civilian hospital in cities across the nation and overseas.
The partnership has reached Athens, Greece, and is about to extend into Malaysia. "We're about to circle the globe," he said.
Peoples attributed much of the program's successes to this military-civilian network. "We're very fortunate to have great partners," he said.
He also praised the military men and women willing to take part in the trials. They enter into them knowing they may be part of the control group that doesn't receive a potentially lifesaving vaccine. Despite that fact, he hasn't seen a shortage of willing participants, Peoples said.
"The military is an ideal setting for clinical trials," he said.
Service members, retirees and family members have a strong sense of service, he noted. "They want to be involved and contribute to the research," he added.

While they're focusing on secondary cancer prevention, the ultimate goal, Peoples noted, is primary prevention, meaning cancer prevention among people with a predicted risk of cancer based on family history and genetic markers.
"Hopefully, sometime in my lifetime we'll figure that out," he said.
Related Sites:
San Antonio Military Medical Center 

Welcome to PM of the Republic of Trinidad

The Prime Minister, Dr. Manmohan Singh meeting the Prime Minister of the Republic of Trinidad and Tobago, Mrs. Kamla Persad-Bissessar, at her ceremonial reception, at Rashtrapati Bhavan, in New Delhi on January 06, 2012. Smt. Gursharan Kaur and Dr. Gregory Bissessar are also seen.